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SUMMARY:Bradford Hill Seminar - Leveraging External Data for Testing Experimental Therapies with Biomarker Interactions in Randomized Clinical Trials
DESCRIPTION:All are invited to the hybrid Bradford Hill Seminar: \nLeveraging External Data for Testing Experimental Therapies with Biomarker Interactions in Randomized Clinical Trials\nProfessor Lorenzo Trippa\nHarvard T.H. Chan School of Public Health and Dana-Farber Cancer Institute \nRegister to attend\nPlease note this will be a hybrid event. \nAttend in person at: Large Downstairs Teaching Room\, East Forvie Building\, Forvie Site\, Robinson Way\, Cambridge CB2 0SR. \nRegister to attend online at: cam-ac-uk.zoom.us/meeting/register/f9LMsIBDQwqxwpWM0Fr9Hw#/registration \n  \nAbstract\nIn oncology the efficacy of novel therapeutics often differs across patient subgroups\, and these variations are difficult to predict during the initial phases of the drug development process. The relation between the power of randomized clinical trials and heterogeneous treatment effects has been discussed by several authors. In particular\, false negative results are likely to occur when the treatment effects concentrate in a subpopulation but the study design did not account for potential heterogeneous treatment effects. The use of external data from completed clinical studies and electronic health records has the potential to improve decision-making throughout the development of new therapeutics\, from early-stage trials to registration. \nHere we discuss the use of external data to evaluate experimental treatments with potential heterogeneous treatment effects. We introduce a permutation procedure to test\, at the completion of a randomized clinical trial\, the null hypothesis that the experimental therapy does not improve the primary outcomes in any subpopulation. The permutation test leverages the available external data to increase power. Also\, the procedure controls the false positive rate at the desired 𝛼-level without restrictive assumptions on the external data\, for example\, in scenarios with unmeasured confounders\, different pre-treatment patient profiles in the trial population compared to the external data\, and other discrepancies between the trial and the external data. We illustrate that the permutation test is optimal according to an interpretable criteria and discuss examples based on asymptotic results and simulations\, followed by a retrospective analysis of individual patient-level data from a collection of glioblastoma clinical trials. \nAbout Professor Trippa\nLorenzo Trippa\, PhD\, is a professor of biostatistics at Harvard T.H. Chan School of Public Health and Dana-Farber Cancer Institute. His research focuses on statistical methods for clinical trial design\, with an emphasis on Bayesian and adaptive approaches\, external controls\, and precision oncology. Trippa’s work aims to improve the efficiency and reliability of trials in complex settings\, particularly in cancer research\, and has connects methodological research and applied clinical studies. \nAbout the Bradford Hill seminars\nThe Bradford Hill seminar series is the principal series of The Cambridge Population Health Sciences Partnership\, in collaboration with the PHG Foundation. This comprises the Departments of Public Health & Primary Care\, MRC Biostatistics Unit and MRC Epidemiology Unit at the University of Cambridge\, bringing together a multi-disciplinary partnership of academics and public health professionals. The Bradford Hill seminar programme of internationally recognised speakers covers topics of broad interest to our public health research community. It aims to transcend as well as connect the activities of our individual partners. \nAll are welcome at our Bradford Hill seminars.
URL:https://www.phs.group.cam.ac.uk/event/bradford-hill-seminar-leveraging-external-data-for-testing-experimental-therapies/
LOCATION:Large Downstairs Teaching Room\, East Forvie Building\, Forvie Site\, Robinson Way\, Cambridge CB2 0SR\, East Forvie Building\, Cambridge\, Cambridgeshire\, CB2 0SR\, United Kingdom
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DTSTART;TZID=Europe/London:20260611T150000
DTEND;TZID=Europe/London:20260611T160000
DTSTAMP:20260514T003047
CREATED:20260415T121908Z
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SUMMARY:Bradford Hill Seminar - From Plate to Brain: Global Diet\, Cognitive Function and Neuroimaging in Diverse Populations
DESCRIPTION:All are invited to the hybrid Bradford Hill Seminar: \nFrom Plate to Brain: Global Diet\, Cognitive Function and Neuroimaging in Diverse Populations\nProfessor Sonia Anand\nMcMaster University\, Ontario\, Canada \nRegister to attend\nPlease note this is free a hybrid event. \nNo registration is required to attend in person. The seminar is being held at – Large Seminar Room\, Cambridge Institute of Public Health\, Forvie Site\, Robinson Way\, Cambridge CB2 0SR. \nRegister in advance to attend the seminar online – https://mrc-epid.zoom.us/meeting/register/8xel5Gx6RvWXR1q8nlieGg \nAbstract\nDrawing on findings from the Canadian Alliance for Healthier Hearts and Minds (CAHHM) and the Prospective Urban Rural Epidemiology (PURE) study\, this seminar will examine how global dietary patterns influence cognitive performance and brain structure across diverse populations. Dr. Anand will highlight evidence linking diet quality and cardiometabolic risk to cognition and neuroimaging markers of brain health in multi‑ethnic and international cohorts. The presentation will discuss implications for prevention strategies that connect nutrition\, vascular health\, and brain aging from a global perspective. \nAbout Professor Sonia Anand\nDr. Sonia Anand is a distinguished physician-scientist and global health leader whose work has transformed Canada’s approach to cardiovascular health\, health equity\, and Indigenous and population health research. She serves as Associate Vice-President of Global Health and Professor of Medicine and Epidemiology at McMaster University and holds a Heart & Stroke Chair recognizing her national impact. Dr. Anand’s research has revealed how sex\, ethnicity\, and social determinants influence cardiometabolic risk—shifting practice away from “one-size-fitsall” models toward equity-focused care. Her studies have set new standards for defining obesity\, created validated ethnic-specific risk scoring systems\, and led to the development and testing of community-based interventions in South Asian and Indigenous populations. Her findings have shaped clinical guidelines\, policy frameworks\, and global conversations on health equity. \nAbout the Bradford Hill seminars\nThe Bradford Hill seminar series is the principal series of The Cambridge Population Health Sciences Partnership\, in collaboration with the PHG Foundation. This comprises the Departments of Public Health & Primary Care\, MRC Biostatistics Unit and IMS Epidemiology at the University of Cambridge\, bringing together a multi-disciplinary partnership of academics and public health professionals. The Bradford Hill seminar programme of internationally recognised speakers covers topics of broad interest to our public health research community. It aims to transcend as well as connect the activities of our individual partners. \nAll are welcome at our Bradford Hill seminars. \n  \n 
URL:https://www.phs.group.cam.ac.uk/event/bradford-hill-seminar-from-plate-to-brain-global-diet-cognitive-function-and-neuroimaging-in-diverse-populations/
LOCATION:Large Seminar Room\, East Forvie Building\, Forvie Site\, Robinson Way\, Cambridge\, CB2 0SR
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