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DTSTART;TZID=Europe/London:20251126T130000
DTEND;TZID=Europe/London:20251126T140000
DTSTAMP:20260514T002830
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UID:1837-1764162000-1764165600@www.phs.group.cam.ac.uk
SUMMARY:Bradford Hill Seminar - Diagnostic and predictive journeys: Finding the right balance in genomic medicine
DESCRIPTION:All are invited to the rescheduled Bradford Hill Seminar: \nDiagnostic and predictive journeys: Finding the right balance in genomic medicine\nProfessor Anneke Lucassen\n Professor of Genomic Medicine\, University of Oxford \nRegister to attend\nPlease note this will be a free online seminar\, \nRegister at https://events.teams.microsoft.com/event/e9735899-dca7-4747-b8e7-78e68fd4505c@49a50445-bdfa-4b79-ade3-547b4f3986e9 \nAbstract\nThe growing use of genomic data in healthcare aims to balance predictive and diagnostic needs by supporting both disease prevention and clinical decision-making. Yet\, the predictive potential of genomic information is frequently overstated\, with the genome too often portrayed as a complete “blueprint” for health. Achieving an effective balance remains challenging\, as genomic applications in public health prediction and clinical diagnosis continue to operate largely in isolation. \nAbout Professor Lucassen\nProfessor Anneke Lucassen is Director of the Centre for Personalised Medicine\, and a physician who specializes in clinical genetics. She is Professor of Genomic Medicine and consultant in clinical genetics at the University of Oxford (since 2021). She leads a research group at the University of Oxford that explores the clinical ethical\, legal and societal issues (CELS) involved in developments in genomics and big data within medicine. \nIn Oxford\, she directs the Centre for Personalised Medicine\, an interdisciplinary environment\, driving forward a more integrated and personalised approach to medicine and healthcare. Having served as chair of the British Society for Genetic Medicine (BSGM) from 2016 to 2020\, Anneke now chairs the ethics advisory committee of UK Biobank and the Joint Committee on Genomics in Medicine (JCGM). \nAbout the Bradford Hill seminars\nThe Bradford Hill seminar series is the principal series of The Cambridge Population Health Sciences Partnership\, in collaboration with the PHG Foundation. This comprises the Departments of Public Health & Primary Care\, MRC Biostatistics Unit and MRC Epidemiology Unit at the University of Cambridge\, bringing together a multi-disciplinary partnership of academics and public health professionals. The Bradford Hill seminar programme of internationally recognised speakers covers topics of broad interest to our public health research community. It aims to transcend as well as connect the activities of our individual partners. \nAll are welcome at our Bradford Hill seminars.
URL:https://www.phs.group.cam.ac.uk/event/bradford-hill-seminar-diagnostic-and-predictive-journeys-finding-the-right-balance-in-genomic-medicine/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/London:20251210T130000
DTEND;TZID=Europe/London:20251210T140000
DTSTAMP:20260514T002830
CREATED:20251127T142529Z
LAST-MODIFIED:20251127T142529Z
UID:1969-1765371600-1765375200@www.phs.group.cam.ac.uk
SUMMARY:Bradford Hill Seminar - From Genes to Public Health: The Journey Continues!
DESCRIPTION:All are invited to the online Bradford Hill Seminar: \nFrom Genes to Public Health: The Journey Continues!\nDr Muin J. Khoury\nEmory University School of Public Health and University of Washington School of Public Health \nRegister to attend\nPlease note this will be a free online seminar\, \nRegister at https://events.teams.microsoft.com/event/a94d948f-ff86-4256-bd91-c14c5adf1841@49a50445-bdfa-4b79-ade3-547b4f3986e9 \nAbstract\nDr. Muin J. Khoury recently retired from the CDC after a 40-year public health career\, including 26 years leading the Office of Public Health Genomics\, which he formed in 1998. He contributed to the development of genetic epidemiology\, public health genomics\, and precision public health; fields that are vital for realising the population health benefits of genome discoveries. \nThe trajectory from genes to public health is still early but Dr Khoury believes the next 40 years promise to be even more exciting in applying these fields to save lives\, prevent disease\, and reduce health inequities. Dr Khoury warns that many of the advances in genomics translation and implementation could be unravelled because of the current turmoil and budget cuts in science and public health in the United States. This talk offers his perspective on the evolution and contributions of these fields\, and recommendations for increasing their population health impact. \nAbout Dr Muin J. Khoury\nDr Khoury was the founding and only Director (1998-2024\, retired) of the Office of Public Health Genomics at the U.S. Centers for Disease Control and Prevention (CDC)\, established to assess the public health impact of the Human Genome Project. He is currently an adjunct Professor of Epidemiology at the Emory Rollins School of Public Health in Atlanta\, Georgia\, and affiliate professor in the Public Health Genetics Institute at the University of Washington in Seattle\, Washington. He also serves on the editorial boards of multiple scientific journals. \nDr Khoury holds an M.D.\, and a Ph.D. in Human Genetics/Genetic Epidemiology. During his 40-year career in public health\, he spearheaded numerous national and international initiatives to translate advances in genomics and other technologies into effective\, ethical interventions to improve population health and reduce inequities. He has extensively published on genetic epidemiology\, public health genomics\, and precision public health\, including four books\, and won multiple scientific and service awards for his contributions to the field. \nAbout the Bradford Hill seminars\nThe Bradford Hill seminar series is the principal series of The Cambridge Population Health Sciences Partnership\, in collaboration with the PHG Foundation. This comprises the Departments of Public Health & Primary Care\, MRC Biostatistics Unit and MRC Epidemiology Unit at the University of Cambridge\, bringing together a multi-disciplinary partnership of academics and public health professionals. The Bradford Hill seminar programme of internationally recognised speakers covers topics of broad interest to our public health research community. It aims to transcend as well as connect the activities of our individual partners. \nAll are welcome at our Bradford Hill seminars.
URL:https://www.phs.group.cam.ac.uk/event/bradford-hill-seminar-from-genes-to-public-health-the-journey-continues/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/London:20260114T130000
DTEND;TZID=Europe/London:20260114T140000
DTSTAMP:20260514T002830
CREATED:20251218T182414Z
LAST-MODIFIED:20260105T111602Z
UID:2053-1768395600-1768399200@www.phs.group.cam.ac.uk
SUMMARY:Bradford Hill Seminar - Expanding testing of cancer susceptibility genes from the clinic to the population: exploring the evidence gaps
DESCRIPTION:All are invited to the in-person Bradford Hill Seminar: \nExpanding testing of cancer susceptibility genes from the clinic to the population: exploring the evidence gaps\nProfessor Clare Turnbull\nInstitute of Cancer Research \nRegister to attend\nPlease note this will be an in-person (Large Seminar Room\, East Forvie Building\, Forvie Site\, Robinson Way\, Cambridge CB2 0SR). \nRegister in advance to attend at: \nhttps://www.phgfoundation.org/upcoming-event/expanding-testing-of-cancer-susceptibility-genes-from-the-clinic-to-the-population-exploring-the-evidence-gaps/ \nAbstract\nTraditionally\, clinical genetics services offered ‘reactive’ testing of specific cancer susceptibility genes (CSGs) to those with the corresponding classical presentation. Increasingly\, cancer susceptibility gene germline pathogenic variants (CSG-GPVs) are being looked for much more ‘proactively’\, including wide germline\, tumour and/or ctDNA genomic analyses performed routinely in cancer patients to inform oncological therapeutics\, return of secondary findings\, direct-to-consumer offerings and population genomic testing programmes. Thus\, whilst CSG-GPVs were historically identified reactively in individuals (and their families) who already knew themselves to have ‘extreme’ disease (young onset\, syndromic or familial cancers)\, CSG-GPVs are increasingly being identified proactively in individuals not previously concerned about genetic cancer susceptibility\, namely (i) via a ‘routine’ cancer presentation\, (ii) coincidental to their presenting cancer or (iii) in the well population. Within this new landscape of assigning many more to individuals to the lifelong implications of being a CSG-GPV-carrier\, it is critical to evaluate the robustness of evidence regarding disease penetrance and the efficacy of our interventions for early detection and prevention\, to ensure such assignations provide net benefit over harm. \nAbout Professor Clare Turnbull\nClare is Professor of Translational Cancer Genetics in the Division of Genetics and Epidemiology at the Institute of Cancer Research\, London and an NHS consultant in Clinical Cancer Genetics at The Royal Marsden. Her research focuses on statistical\, population and public-health-related analyses to inform clinical implementation of cancer susceptibility genetics. Research areas include (i) discovery of novel genes/genomic variants associated with cancer susceptibility (iii) Clinical interpretation of variant pathogenicity (iii) assembly\, linkage and longitudinal analyses of routine NHS datasets\, including working with NDRS to achieve nationally comprehensive submissions of genetic data from NHS genomic laboratory hubs (iv) evaluation of the clinical utility and impact of genomic risk stratification for cancer early detection and prevention. A key area of focus over the last five years has been working in partnership with CRUK and NHS England Cancer Programme on development of pragmatic\, high-throughput pathways for scaling of NHS genomic testing\, focusing first on the BRCA genes (including the BRCA-DIRECT North Thames mainstreaming programme\, the national NHS Jewish Community BRCA testing programme and the national NHS Retrospective BRCA-testing programme). \nClare studied undergraduate medicine at Cambridge\, clinical medicine at Oxford\, undertook a Masters in epidemiology and public health at the London School of Hygiene and Tropical Medicine and a PhD in statistical genetics at The Institute of Cancer Research. From 2015 to 2020\, Clare worked at Genomics England as Clinical Lead for Cancer Genomics for the 100\,000 Genomes Project \nAbout the Bradford Hill seminars\nThe Bradford Hill seminar series is the principal series of The Cambridge Population Health Sciences Partnership\, in collaboration with the PHG Foundation. This comprises the Departments of Public Health & Primary Care\, MRC Biostatistics Unit and MRC Epidemiology Unit at the University of Cambridge\, bringing together a multi-disciplinary partnership of academics and public health professionals. The Bradford Hill seminar programme of internationally recognised speakers covers topics of broad interest to our public health research community. It aims to transcend as well as connect the activities of our individual partners. \nAll are welcome at our Bradford Hill seminars.
URL:https://www.phs.group.cam.ac.uk/event/bradford-hill-seminar-expanding-testing-of-cancer-susceptibility-genes-from-the-clinic-to-the-population-exploring-the-evidence-gaps/
LOCATION:Large Seminar Room\, East Forvie Building\, Forvie Site\, Robinson Way\, Cambridge\, CB2 0SR
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BEGIN:VEVENT
DTSTART;TZID=Europe/London:20260227T130000
DTEND;TZID=Europe/London:20260227T140000
DTSTAMP:20260514T002830
CREATED:20260203T174142Z
LAST-MODIFIED:20260408T103509Z
UID:2107-1772197200-1772200800@www.phs.group.cam.ac.uk
SUMMARY:Bradford Hill Seminar - Leveraging External Data for Testing Experimental Therapies with Biomarker Interactions in Randomized Clinical Trials
DESCRIPTION:All are invited to the hybrid Bradford Hill Seminar: \nLeveraging External Data for Testing Experimental Therapies with Biomarker Interactions in Randomized Clinical Trials\nProfessor Lorenzo Trippa\nHarvard T.H. Chan School of Public Health and Dana-Farber Cancer Institute \nRegister to attend\nPlease note this will be a hybrid event. \nAttend in person at: Large Downstairs Teaching Room\, East Forvie Building\, Forvie Site\, Robinson Way\, Cambridge CB2 0SR. \nRegister to attend online at: cam-ac-uk.zoom.us/meeting/register/f9LMsIBDQwqxwpWM0Fr9Hw#/registration \n  \nAbstract\nIn oncology the efficacy of novel therapeutics often differs across patient subgroups\, and these variations are difficult to predict during the initial phases of the drug development process. The relation between the power of randomized clinical trials and heterogeneous treatment effects has been discussed by several authors. In particular\, false negative results are likely to occur when the treatment effects concentrate in a subpopulation but the study design did not account for potential heterogeneous treatment effects. The use of external data from completed clinical studies and electronic health records has the potential to improve decision-making throughout the development of new therapeutics\, from early-stage trials to registration. \nHere we discuss the use of external data to evaluate experimental treatments with potential heterogeneous treatment effects. We introduce a permutation procedure to test\, at the completion of a randomized clinical trial\, the null hypothesis that the experimental therapy does not improve the primary outcomes in any subpopulation. The permutation test leverages the available external data to increase power. Also\, the procedure controls the false positive rate at the desired 𝛼-level without restrictive assumptions on the external data\, for example\, in scenarios with unmeasured confounders\, different pre-treatment patient profiles in the trial population compared to the external data\, and other discrepancies between the trial and the external data. We illustrate that the permutation test is optimal according to an interpretable criteria and discuss examples based on asymptotic results and simulations\, followed by a retrospective analysis of individual patient-level data from a collection of glioblastoma clinical trials. \nAbout Professor Trippa\nLorenzo Trippa\, PhD\, is a professor of biostatistics at Harvard T.H. Chan School of Public Health and Dana-Farber Cancer Institute. His research focuses on statistical methods for clinical trial design\, with an emphasis on Bayesian and adaptive approaches\, external controls\, and precision oncology. Trippa’s work aims to improve the efficiency and reliability of trials in complex settings\, particularly in cancer research\, and has connects methodological research and applied clinical studies. \nAbout the Bradford Hill seminars\nThe Bradford Hill seminar series is the principal series of The Cambridge Population Health Sciences Partnership\, in collaboration with the PHG Foundation. This comprises the Departments of Public Health & Primary Care\, MRC Biostatistics Unit and MRC Epidemiology Unit at the University of Cambridge\, bringing together a multi-disciplinary partnership of academics and public health professionals. The Bradford Hill seminar programme of internationally recognised speakers covers topics of broad interest to our public health research community. It aims to transcend as well as connect the activities of our individual partners. \nAll are welcome at our Bradford Hill seminars.
URL:https://www.phs.group.cam.ac.uk/event/bradford-hill-seminar-leveraging-external-data-for-testing-experimental-therapies/
LOCATION:Large Downstairs Teaching Room\, East Forvie Building\, Forvie Site\, Robinson Way\, Cambridge CB2 0SR\, East Forvie Building\, Cambridge\, Cambridgeshire\, CB2 0SR\, United Kingdom
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/London:20260611T150000
DTEND;TZID=Europe/London:20260611T160000
DTSTAMP:20260514T002830
CREATED:20260415T121908Z
LAST-MODIFIED:20260422T145048Z
UID:2302-1781190000-1781193600@www.phs.group.cam.ac.uk
SUMMARY:Bradford Hill Seminar - From Plate to Brain: Global Diet\, Cognitive Function and Neuroimaging in Diverse Populations
DESCRIPTION:All are invited to the hybrid Bradford Hill Seminar: \nFrom Plate to Brain: Global Diet\, Cognitive Function and Neuroimaging in Diverse Populations\nProfessor Sonia Anand\nMcMaster University\, Ontario\, Canada \nRegister to attend\nPlease note this is free a hybrid event. \nNo registration is required to attend in person. The seminar is being held at – Large Seminar Room\, Cambridge Institute of Public Health\, Forvie Site\, Robinson Way\, Cambridge CB2 0SR. \nRegister in advance to attend the seminar online – https://mrc-epid.zoom.us/meeting/register/8xel5Gx6RvWXR1q8nlieGg \nAbstract\nDrawing on findings from the Canadian Alliance for Healthier Hearts and Minds (CAHHM) and the Prospective Urban Rural Epidemiology (PURE) study\, this seminar will examine how global dietary patterns influence cognitive performance and brain structure across diverse populations. Dr. Anand will highlight evidence linking diet quality and cardiometabolic risk to cognition and neuroimaging markers of brain health in multi‑ethnic and international cohorts. The presentation will discuss implications for prevention strategies that connect nutrition\, vascular health\, and brain aging from a global perspective. \nAbout Professor Sonia Anand\nDr. Sonia Anand is a distinguished physician-scientist and global health leader whose work has transformed Canada’s approach to cardiovascular health\, health equity\, and Indigenous and population health research. She serves as Associate Vice-President of Global Health and Professor of Medicine and Epidemiology at McMaster University and holds a Heart & Stroke Chair recognizing her national impact. Dr. Anand’s research has revealed how sex\, ethnicity\, and social determinants influence cardiometabolic risk—shifting practice away from “one-size-fitsall” models toward equity-focused care. Her studies have set new standards for defining obesity\, created validated ethnic-specific risk scoring systems\, and led to the development and testing of community-based interventions in South Asian and Indigenous populations. Her findings have shaped clinical guidelines\, policy frameworks\, and global conversations on health equity. \nAbout the Bradford Hill seminars\nThe Bradford Hill seminar series is the principal series of The Cambridge Population Health Sciences Partnership\, in collaboration with the PHG Foundation. This comprises the Departments of Public Health & Primary Care\, MRC Biostatistics Unit and IMS Epidemiology at the University of Cambridge\, bringing together a multi-disciplinary partnership of academics and public health professionals. The Bradford Hill seminar programme of internationally recognised speakers covers topics of broad interest to our public health research community. It aims to transcend as well as connect the activities of our individual partners. \nAll are welcome at our Bradford Hill seminars. \n  \n 
URL:https://www.phs.group.cam.ac.uk/event/bradford-hill-seminar-from-plate-to-brain-global-diet-cognitive-function-and-neuroimaging-in-diverse-populations/
LOCATION:Large Seminar Room\, East Forvie Building\, Forvie Site\, Robinson Way\, Cambridge\, CB2 0SR
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